Founder of PersonalGenomes.org, which provides the world's only open-access information on human Genomic, Environmental & Trait data (GET). His 1984 Harvard PhD included the first methods for direct genome sequencing, molecular multiplexing & barcoding. These led to the first genome sequence (pathogen, Helicobacter pylori) in 1994. His innovations have contributed to nearly all "next generation" DNA sequencing methods & companies. This plus his lab's work on chip-DNA-synthesis, gene editing & stem cell engineering resulted in founding additional application-based companies in medical diagnostics, synthetic biology and therapeutics. He has also pioneered new privacy, biosafety, ELSI, environmental & biosecurity policies. He is director of an IARPA BRAIN Project & NIH Center for Excellence in Genomic Science. His honors include election to NAS & NAE & Franklin Bower Laureate for Achievement in Science. He has coauthored 425 papers, 95 patent publications & one book (Regenesis).