David I Smith received his Ph.D. in Biochemistry from the University of Wisconsin in Madison in 1978. After postdoctoral fellowships at the Albert Einstein College of Medicine and the University of California, Irvine, he became an Assistant Professor at Wayne State University in 1985. In 1996 he joined the Department of Laboratory Medicine and Pathology at the Mayo Clinic. He is currently the head of the Technology Assessment Committee for the Mayo Clinic Center for Individualized Medicine with the responsibility of evaluating new technologies that could have a dramatic impact on basic research and its’ clinical translation. His laboratory studies the common fragile sites which are regions of profound instability found in all individuals. His laboratory also studies the various ways that human papillomavirus (HPV) is involved in the development of different cancers. He has been actively collaborating with BGI for the past several years and has with them been using whole genome sequencing to study the physical status of HPV in oropharyngeal squamous cell carcinomas.