1965 B.A. (Moderatorship in Genetics), Trinity College, Dublin University.
1970 Ph.D. Dublin University (TCD). (1967-1969 in University of Cincinnati) 1981 Sc.D. Dublin Univ. (External examiner, F. Sanger).
1969-71 EMBO Long Term Fellow, Dept. of Molecular Biology, University of Århus, Denmark
1971-72 I.C.R.F. Fellow, Cancer Research UK (present name), London.
1972-75 & ’77-‘78 Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. 1975-77 Senior Scientific Officer ICI Corporate Lab (prior to the formation of Zeneca and AstraZeneca) Runcorn, England, on secondment to the Department of Molecular Biology, University of Edinburgh, for a Joint research scheme.
1978-80 Research Associate, Howard Hughes Medical Institute, U. of Utah.
1981 EMBO Short Term Fellow, Dept. of Molecular Biology, University of Geneva 1981-86 College and later Statutory Lecturer, Dept. of Biochemistry, UCC, Ireland.
1983 First Irish elected member of EMBO
1986- Research Associate Prof, then Research Prof. Department of Human Genetics, University of Utah – currently Emeritus status.
1997- Honorary Professor of Genetics, Department of Genetics, Trinity College Dublin, Ireland.
2002-03 1st Director of Life Sciences, Science Foundation Ireland.
2004- Research Professor, Biochemistry and also Microbiology, University College Cork, Ireland (later via UCC Academy DAC).
2007 First Royal Irish Academy gold medal for the Life Sciencaes.
2015 Member of review panel in Berlin of a Deutsche Forschungsgemeinschaft (DFG) Research Programme (1805/2).
non-standard genetic readout enriches gene expression: Detecting diverse mRNA
College Cork, Western Gateway Building, Cork T12 YT57, Ireland
Both the meaning of individual codons and the
framing of the readout process can be modified by information in specific
mRNAs. Dynamic redefinition of codon meaning often but not exclusively involves
UAG or UGA. Both it and programmed ribosomal frameshifting, are widely used in
viral decoding especially of RNA viruses, but important instances of regulatory
usage are known in cellular gene decoding. This translational recoding is paralleled
by productive utilization of specific transcriptional slippage that can be
programmed, for instance by nascent RNA forming structure within the
polymerase. The diversity of signals for utilized transcriptional and
translational non-standard readout will be described, together with comments on
the value of the potential for future direct RNA sequence information.