My laboratory’s expertise is in genome editing and gene therapies. I have received my Ph.D. degree in 2007 and postdoctoral training during 2012 to 2014. I have gained China Youth Thousand Talents Program in 2014 and Outstanding Youth Science Foundation in 2015. I began my research career as a pioneer making genetically modified mice including semi-cloned mice by androgenetic haploid stem cells and CRISPR-editing mice, some of which have produced important advances in understanding genetic diseases, and developmental abnormalities.Recently,the lab has demonstrated thatfully functional knockout monkey in F0 and knock-in monkey could be generated by optimized CRISPR/Cas9 system. We have also demonstrated the use of the CRISPR/Cas9 system to eliminate targeted chromosomes via multiple DNA cleavages, offering a new therapeutic strategy for human aneuploidy diseases involving additional chromosomes.My group is interested in establishing a powerful platform to generate genetically humanized animals, including rodent and non-human primate, and develop an efficient genetic approach to correct genetic diseases in these humanized animal models.