Speakers at ICG-13

Dr. Wu’s main research interests are focused on thegeneration of new pluripotent stem cells (PSCs) for gaining novel insights in basic biology and developing new translational applications, as well as developing novel and efficient genome and epi-genome editing tools.He has expanded the spectrum of pluripotent states by capturing novel pluripotent stem cells with distinct molecular and phenotypic featuresand derived novel PSCs from several rodent, livestock and primate species. Dr. Wu has also helped develop a robust homology-independent targeted integration (HITI) strategy that allows for efficient DNA knock-in in both dividing and non-dividing cells in vitro and in vivo, and a stable and wide range DNA methylation method based on targeted insertion of CpG free sequence in CpG islands in pluripotent stem cells (PSCs). Moreover, together with his collaborators, Dr. Wu helped devise effective strategies to safely repair disease-causing mitochondria and nuclear DNA mutations in one-cell human embryos. More recently, Dr. Wu has succeeded in generating PSC-derived interspecies chimeras and developed an efficient and versatile interspecies blastocyst complementation system for organ generation, which bodes hope for solving the severe worldwide shortage of donor organs.

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