Speakers at ICG-13

Speakers at ICG-13

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Biography

As the past Director of the Human Genome Project for US. Department of Energy, Dr. Hawkins has built a recognized career in the healthcare industry over the past 25 years spanning business, academic innovation and as an entrepreneur.

 

Dr. Hawkins is currently the Founder & Managing Partner at IGenes LLC, a consulting and investment firm working with a portfolio of global companies. Clients include General Electric, Ping An, Google, Grifols, Ativa Medical, Data Cubed, EdenRoc Sciences and BioElectron.

 

IGenes LLC provides consulting services to companies ranging from technology roadmaps, strategy development and evaluation, market modeling, product development roadmaps and regulatory approval.

 

Previously, Dr. Hawkins has held several senior executive roles at Siemens Healthcare, Philips and General Electric. He was also a successful entrepreneur building and selling a diagnostic company based in Shanghai & San Francisco.

 

Dr. Hawkins has published over 50 peer-reviewed articles on automation, genomics, human diseases and the human genome project in addition to writing a book, “Solving the Healthcare Equation” which is expected to be completed in 2019.


Abstract

BioElectronic Medicine enables a whole new approach to personalized therapies

Victoria Cotero1, Ying Fan1, Ileana Hancu1, Paul Fitzgerald1, Kirk Wallace1, Sireesha Kaanumalle1, Wayne Rigby1, Tzu-Jen Kao1, Jeanette Roberts1, Chitresh Bhushan1, Suresh Joel1, Sangeeta S. Chavan2, Stavros Zanos2, Kevin J. Tracey2, Jeffrey Ashe1, Christopher Puleo1, Trevor Hawkins3

1GE Global Research Center, 1 Research Circle, Niskayuna, NY 12309

2Feinstein Institute for Medical Research, 350 Community Dr., Manhasset, NY, 11020

3Advisor to GE Corporate, 2882 Sand Hill Road, Menlo Park, CA 94025

Bio Electronic Medicine is an emerging field which potentially opens up a whole new area of using nerve stimulation to moderate biochemical responses in the body. Applications in pain management, inflammation and metabolic diseases such as diabetes are on the horizon. In a joint program between GE Corporate, GE Research Center and Northwell Health, the Center for Bio Electronic Medicine was created to advance this field and drive early developments to commercialization.

The team have demonstrated a noninvasive method to modulate specific signaling pathways within organs using ultrasound (US). US was first applied to the spleen and found to modulate neuroimmune pathways involved in cytokine regulation. Optimal US stimulation parameters were found that reduced cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). In separate experiments, US stimulation of the liver was shown to modulate pathways that regulate blood glucose and was as effective as VNS in suppressing the hyperglycemic effect of endotoxin exposure. These data demonstrate that US stimulation within organs provides a new method for site-selective neuromodulation with the capability to alter specific physiological functions and potentially treat inflammatory and other health disorders, opening up whole new areas of personalized medicine. 
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